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Biodesign Directory Profile

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Contact Information

480-225-9412

Charles Arntzen, PhD Regents Professor

Florence Ely Nelson Presidential Endowed Chair

Professor

The Biodesign Institute, Infectious Diseases and Vaccinology

Professor

College of Liberal Arts and Sciences, School of Life Sciences

Bio

Charles J. Arntzen was appointed to the Florence Ely Nelson Presidential Endowed Chair at Arizona State University in Tempe in 2000 and as Regents Professor in 2004. He served as the Founding Director of The Biodesign Institute until May, 2003, and as Co-Director of the Center for Infectious Diseases and Vaccinology of that Institute until 2007. He has served  as Director for two NIH-funded Cooperative Research Centers at ASU - one for Hepatitis C vaccine development, and a second for mucosal vaccines and microbicides to prevent sexually-transmitted infections.

Dr. Arntzen held previous faculty positions at the University of Illinois and Michigan State University, and visiting professorships in the Laboratoire de Photosynthese du CNRS in France, the Department of Applied Mathematics in Canberra, Australia, and the Academia Sinica in Beijing, China. He also served as a research scientist with the USDA and as the director of the Michigan State University-Plant Research Laboratory (funded by the Department of Energy). In 1984 he joined the DuPont Company in Wilmington, Delaware as Director of Plant Science and Microbiology and was later promoted to Director of Biotechnology in the Agricultural Products Department. In 1988 he was appointed Dean and Deputy Chancellor for Agriculture at Texas A&M University, and subsequently served as Director of the University's Plant Biotechnology Program of the Institute of Biosciences and Technology. From 1995-2000, Dr. Arntzen served as President and CEO of Boyce Thompson Institute - a not-for-profit corporation affiliated with Cornell University.

Dr. Arntzen was elected to the U.S. National Academy of Sciences in 1983 and to the National Academy of Sciences in India the following year. He is a fellow of The American Association for the Advancement of Science (AAAS) and also of the American Society of Plant Biologists, received the Award for Superior Service from the U.S. Department of Agriculture for international project leadership in India, the American Society of Plant Biology Leadership in Science Public Service Award in 2004, and the Botanical Society of America Centennial Award in 2007. He received the degree of Doctor of Science honoris causa from Purdue University in 1997, the University of Minnesota in 2003, and the Hebrew University in Jerusalem in 2008. He has been a member of numerous national and international committees that serve general scientific interests, and in 2003 was awarded the Selby Fellowship by the Australian Academy of Sciences. He was a member of the Executive Committee of the Board of Governors of the University of Chicago for the Argonne National Laboratory and served as chairperson of their Science and Technology Advisory Committee. He served as chairman of the National Biotechnology Policy Board of the National Institutes of Health, as chairman of the National Research Council's Committee on Biobased Industrial Products, and on the National Research Council's Committee on Space Biology and Medicine. He served for eight years on the Editorial Board of SCIENCE. In 2011-12 he served as Chair of Section O "Agriculture, Food, and Renewable Resources" of the AAAS.

Dr. Arntzen served until 1998 on the Board of Directors of DeKalb Genetics, Inc. and on the Board of Directors of Third Wave Agbio, Inc. and on the Scientific Advisory Board for Sumitomo Chemical Company in Osaka, Japan until 2001. He now serves on the Board of Directors of Advanced BioNutrition, Inc., and is on the Advisory Board of the Burrill and Companys Agbio Capital Fund and The Nutraceuticals Fund. He also serves as a Distinguished Advisor on the Council for Biotechnology. From 2001-2008 he served as a member of President George W. Bush's Council of Advisors on Science & Technology in the Office of Science and Technology Policy, and in 2004 he was appointed by the President to serve on the National Nanotechnology Oversight Board from 2004-2008.

Dr. Arntzen's primary research interests are in plant molecular biology and protein engineering, as well as the utilization of plant biotechnology for enhancement of food quality and value, for expression of pharmacologically active products in transgenic plants, and for overcoming health and agricultural constraints in the developing world. He has been recognized as a pioneer in the development of plant-based vaccines for human disease prevention (with special emphasis on needs of poor countries) and for disease prevention in animal agriculture. Recently this research has been extended to creation of effective vaccines and therapeutics to reduce the threats of biowarfare agents.

Dr. Arntzen received his bachelor's and masters degrees from the University of Minnesota and his Ph.D. from Purdue University. He is married to Kathy (Lang) Arntzen, and the father of one son, Christopher Arntzen, a partner in the Corporate Division of the Baker and Botts law firm in Houston, Texas.

Expertise and Research Interests

Basic research in plant molecular biology and protein engineering, as well as the utilization of plant biotechnology for enhancement of food quality and value, for expression of pharmacological products in transgenic plants, and for overcoming health and agricultural constraints in the developing world.

Other Expertise

Director, MSU-DOE Plant Research Laboratory, Michigan State University, 1980-84
Deputy Chancellor for Agriculture, Texas A&M University, 1988-92
Legislative appointee; Texas Department of Agriculture, Agriculture Resources Protection Authority, 1989-92
Member, Board of Governors of the University of Chicago for Argonne National Laboratory. Member Executive Comm.; Chair of Scientific/Technical Advisory Board, 1990-97
Member, National Biotechnology Policy Board, Department of Health and Human Services, National Institutes of Health, 1990-93; Chairman, 1991-93
Member, Keystone Symposia Board of Directors, 1990-1997 ; Executive Committee, 1994-97
Editorial Board, Science, 1991-1998
Chairman, National Research Council Committee on "Biobased Industrial Products: National Research and Commercialization Priorities," 1994-95
Member, NAS/NRC Committee on Space Biology and Medicine, 1995-96
Member, Board of Directors, Boyce Thompson Southwestern Arboretum, 1995-present
Member, President Bush's Council of Advisors in Science and Technology, 2001-2009
Presidental appointment, National Nanotechnology Oversight Board, 2004-2009

Industrial Relevance

Research Director at Dupont de Nemours, 1984-88
Science Advisory Board, Plant Genetic Systems, Inc., (Brussels, Belgium) 1985-87
Science Advisory Board, Advanced Genetic Sciences, Inc. (Oakland, California) 1985-88
Member, Board of Directors, DeKalb Genetics Corporation, 1990-98; Chair, Audit Committee, 1990-98
Member, Board of Scientific Advisors, Phytera, Inc. (formerly Plant Pharmaceuticals, Inc.), 1993-2000
Member, Advisory Board of the Burrill and Company Agbio Capital Fund, 1997-present, and Nutraceutical Capital Fund, 2000-present
Member, Board of Directors, Axis Genetics, PLC (England) 1998-1999
Member, Board of Directors, Third Wave AgBio, Inc. 1998-2001
Member, Monsanto's Integrated Protein Technologies Scientific Advistory Board, 1999-2000
Member, Epicyte Pharmaceutical, Inc Scientific Advistory Board, 2001-2005
Member, Board of Directors, Finance Committee, Applied Bionutrition, Inc., 2001-present
Member, Board of Directors of the National Center for Genome Resources 2005-2011
Founder and Member of the Board of Directors, VAXX, Inc. 2008-2001
Member, Board of Directors, Performance Plants, Inc., 2009-2010

Memberships

American Association for the Advancement of Science
American Society for Plant Biology
Council for Biotechnology Information
National Academy of Sciences
National Academy of Sciences, India

Honors and Awards

2010, Chair Elect; 2011-2012 Chair of Section O (Agriculture, Food, and Renewable Resources) of AAAS
2008, Doctor of Science, honoris causa, The Hebrew University, Jerusalem
2007, Elected Fellow, American Society of Plant Biologists
2006, Botanical Society of America Centennial Award, Botanical Society of America
2004ASPB Leadership in Science Public Service Award, American Society of Plant Biologists
2004-2009, National Nanotechnology Advisory Panel (appointed by George W. Bush), Office of Science and Technology, Office of the President, U.S.A.
2003, Doctor of Science, honoris causa, University of Minnesota
2003, Selby Fellowship, Australian Academy of Sciences
2001-2008, President's Council of Advisors in Science and Technology (for George W. Bush), Executive Office of the President, United States Government
1997, Doctor of Science, honoris causa, School of Science, Purdue University
1994, AAAS Fellow, American Association for the Advancement of Science
1994, The Dennis Robert Hoagland Award, The American Society of Plant Physiologists
1984, Elected to the National Academy of Sciences of India,
1983, Elected to the National Academy of Sciences, USA,
1980, USDA Superior Service Award,
1980, Award of Excellence, Weed Science Society of America
1979, Charles Albert Shull Award, American Society of Plant Physiologists

Previous Positions

2003-2007, Director, Arizona State University, Biodesign Institute, Center for Infectious Diseases and Vaccinology
2001-2003, Founding Director, Arizona State University, Biodesign Institute (formerly Arizona Biomedical Institute)
1995-2000, CEO, Boyce Thompson Institute for Plant Research
1995-2000, President, Boyce Thompson Institute for Plant Research
1994-1995, Adjunct Professor, University of Texas Health Science Center at Houston, Physiology
1992-1995, Program Director, Institute of Biosciences and Technology, Plant Biotechnology
1992-1995, Professor, Texas A&M University, Biochemistry and Biophysics, Institute of Biosciences and Technology
1988-1992, Deputy Chancellor, Texas A&M University, Agriculture
1987-1988, Director, DuPont Company, Biotechnology Research, Agricultural Products
1984-1986, Director, DuPont Company, Plant Science and Microbiology, Central Research and Development
1983, Visiting Scientist, Academia Sinica, Beijing
1981, ANU Fellow, Australian National University, Research School of Physical Sciences, Applied Mathematics
1980-1984, Director, Michigan State University, MSU-DOE Plant Research Laboratory
1978-1980, Professor, University of Illinois at Urbana-Champaign, Botany and Agronomy
1976-1980, Plant Physiologist, USDA/SEA
1976, NATO Scientist, France, Laboratoire de Photosynth?se du CNRS
1974-1978, Associate Professor, University of Illinois at Urbana-Champaign, Biology, Plant Physiology
1973-1974, CNRS-supported Research Scientist in France, Laboratoire de Photosynth?se du CNRS
1970-1974, Assistant Professor, University of Illinois at Urbana-Champaign, Botany, Plant Physiology
1969-1970, NSF Postdoctoral Fellow, Charles F. Kettering Research Laboratory

Publications

2011

  • Phoolcharoen W, Bhoo SH, Lai H, Ma J, Arntzen CJ, Chen Q, Mason HS (2011) Expression of an immunogenic Ebola immune complex in Nicotiana benthamiana., Plant biotechnology journal, 9: no. doi: 10.1111/j.1467-7652.2011.005
  • Velasquez LS, Shira S, Berta AN, Kilbourne J, Medi BM, Tizard I, Ni Y, Arntzen CJ, Herbst-Kralovetz MM (2011) Intranasal delivery of Norwalk virus-like particles formulated in an in situ gelling, dry powder vaccine. Vaccine 29: 32, 5221-31.
  • Phoolcharoen W, Dye JM, Kilbourne J, Piensook K, Pratt WD, Arntzen CJ, Chen Q, Mason HS, Herbst-Kralovetz MM. (2011) A nonreplicating subunit vaccine protects mice against lethal Ebola virus challenge. Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20695-700. Epub 2011 Dec 5. PMID:22143779

2010

  • Huang Z, Phoolcharoen W, Lai H, Piensook K, Cardineau G, Zeitlin L, Whaley KJ, Arntzen CJ, Mason HS, Chen Q (2010) High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system., Biotechnology and bioengineering, 106 (1), 9-17
  • Hjelm BE, Berta AN, Nickerson CA, Arntzen CJ, Herbst-Kralovetz MM (2010) Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model, Biology of reproduction, 82 (3), 617-27
  • Matoba N, Husk AS, Barnett BW, Pickel MM, Arntzen CJ, Takahashi A, Tanno K, Omura S, Montefiori DC, Mooney JP, Cao H, Hanson CV, Tanaka H. (2010) HIV-1 Neutralization Profile and Plant-based Recombinant Expression of Actinohivin, an Env Glycan-specific Lectin Devoid of T-cell Mitogenic Activity.  PLoS ONE 5(6), e11143
  • Velasquez LS, Hjelm BE, Arntzen CJ, Herbst-Kralovetz MM (2010) An intranasally delivered TLR7 agonist elicits robust systemic and mucosal responses to Norwalk virus-like particles. Clinical and vaccine immunology: CVI, 17 (12), 1850-1858
  • Huang Z, Phoolcharoen W, Lai H, Piensook K, Cardineau G, Zeitlin L, Whaley KJ, Arntzen CJ, Mason HS, Chen Q (2010) High-level rapid production of full-size monoclonal antibodies in plants by a single-vector DNA replicon system., Biotechnology and bioengineering, 106 (1), 9-17

2009

  • Huang Z, Chen Q, Hjelm B, Arntzen C, Mason H. (2009). A DNA replicon system for rapid high-level production of virus-like particles in plants. Biotechnology and bioengineering 103(4):706-14
  • Del Prete G, Santi L, Andrianaivoarimanana V, Amedei A, Domarle O, D' Elios MM, Arntzen CJ, Rahalison L, Mason HS (2009) Plant-derived recombinant F1, V, and F1-V fusion antigens of Yersinia pestis activate human cells of the innate and adaptive immune system. Int. J. Immunopath. & Pharmacology, 22 (1), 133-43

2008

  • Santi L, Batchelor L, Huang Z, Hjelm B, Kilbourne J, Arntzen CJ, Chen Q, Mason HS (2008) An efficient plant viral expression system generating orally immunogenic Norwalk virus-like particles., Vaccine, 26 (15), 1846-54

2006

  • Santi L, Giritch A, Roy CJ, Marillonnet S, Klimyuk V, Gleba Y, Webb R, Arntzen CJ, Mason HS.  (2006) Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system.  Proc Natl Acad Sci U S A.  2006 103(4): 861-866.
  • Huang Z, Santi L, LePore K, Kilbourne J, Arntzen CJ, Mason HS. (2006) Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice.  Vaccine. 24(14):2506-13
  • Lee KY, Kim DH, Kang TJ, Kim J, Chung GH, Yoo HS, Arntzen CJ, Yang MS, Jang YS.  (2006). Induction of protective immune responses against the challenge of Actinobacillus pleuropneumoniae by the oral administration of transgenic tobacco plant expressing ApxIIA toxin from the bacteria. FEMS Immunol Med Microbiol. 48(3):381-9.
  • Saldaña S, Esquivel Guadarrama F, Olivera Flores Tde J, Arias N, López S, Arias C, Ruiz-Medrano R, Mason H, Mor T, Richter L, Arntzen CJ, Gómez Lim MA. (2006). Production of rotavirus-like particles in tomato (Lycopersicon esculentum L.) fruit by expression of capsid proteins VP2 and VP6 and immunological studies. Viral Immunol. 19(1):42-53.

2005

  • Arntzen, Charles, Plotkin, S, Dodet, B. Plant-derived Vaccines and Antibodies: Potential and Limitations. Vaccine (2005).
  • Arntzen, Charles, Plotkin, Stanley, Dodet, Betty. Plant-derived vaccines and antibodies: potential and limitations. Vaccine (2005).
  • Bryan, J, Maloney, B J, Takeda, Naokazu, Suzaki, Yuriko, Yasushi, Ami, Li, Tian Cheng, Miyamura, Tatsuo, Arntzen, Charles, Mason, Hugh S. Challenges in creating a vaccine to prevent hepatitis E. Vaccine (2005).
  • Huang, Z, Santi, L, LePore, K, Kilbourne, J, Arntzen, Charles, Mason, H S. Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice. Vaccine (2005).
  • Thanavala, Y, Mahoney, M, Pal, S, Scott, A, Richter, L, Natarajan, N, Goodwin, P, Arntzen, Charles, Mason, H S. Immunogenicity in humans of an edible vaccine for hepatitis B. Proc. Natl. Acad. Sci., U.S (2005).
  • Thanavala, Y, Maoney, M, PaL, S, Scott, A, Richter, L, Natarajan, N, Goodwin, P, Arntzen, Charles, Mason, H. Immunogenicity in Humans of an Edible Vacine for Hepatitis B. Proc. Natl. Acad. Sci., U.S (2005).

2004

  • Mason, H S, Chikwamba, R, Santi, L, Mahoney, R T, Arntzen, Charles. Antigen delivery systems: Transgenic plants for mucosal vaccines. Mucosal Immunology (2004).
  • Mor, T S, Mason, H S, Kirk, D D, Arntzen, Charles, Cardineau, G A. Plants as Production and Delivery Vehicle for Orally Delivered Subunit Vaccines. New Generation Vaccines (2004).
  • Peterson, R K.D, Arntzen, Charles. On risk and plant-based pharmaceuticals. TRENDS in Biotechnology (2004).
  • Rigano, M M, Arntzen, Charles, Pinkhasov, J, Jin, Y, Sala, F, Arntzen, C J, Walmsley, A M. Production of a fusion protein consisting of the enterotoxigenic Escherichia coli heat-labile toxin B subunit and a tuberculosis antigen in Arabadopsis thaliana. Plant Cell Rep (2004).

2003

  • Arntzen, Charles, Coglan, A, Johnson, B, Peacock, J, Rodemeyer, M. GM Crops: Science, Politics and Communication. Nature Reviews Genetics (2003).
  • Arntzen, Charles, Pitman, S. Biotechnology. Encyclopedia of Food and Culture (2003).
  • Rigano, M M, Sala, F, Arntzen, Charles, Walmsley, A M. Targeting of plant-derived vaccine antigens to immunoresponsive mucosal sites. Vaccine (2003).
  • Smith, M L, Ricther, L, Arntzen, Charles, Shuler, M L, Mason, H S. Structral characterization of plant-derived hepatitis B surface antigen employed in oral immunization studies. Vaccine (2003).
  • Walmsley, A M, Alvarez, M L, Jin, Y, Kirk, D D, Lee, S M, Pinkhasov, J, Rigano, M M, Arntzen, Charles, Mason, H S. Expression of the B subunit of Escherichia coli heat-labile enterotoxin as a fusion protein in transgenic tomato. Plant Cell Rep (2003).
  • Walmsley, A M, Arntzen, Charles. Plant cell factories and mucosal vaccines. Current Opinions in Biotechnology (2003).

2002

  • Ganapathi, T, Haridas, V, Gutterman, J U, Arntzen, Charles. Joshi, L., Van Eck, J.M., Mayo, K., Di Silvestro, R., Blake (Nieto), M.E., Metabolomics of plant saponins; Bioprospecting triterpene glycoside diversity with respect to mammalian cell targets. OMICS: Journal of Integrative Biology (2002).
  • Mason, H S, Warzecha, H, Mor, T, Arntzen, Charles. Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. TRENDS in Molecular Medicine (2002).
  • 2001
  • Arntzen, Charles. Agricultural biotechnology. J. Sci. Food Agric (2001).
  • Arntzen, Charles, Chalmers, I. The risks and rewards of biotechnology. Gastronomica (2001).
  • Ganapathi, T R, Higgs, N S, Balint-Kurti, P J, Arntzen, Charles, May, G D, Van Eck, J M. Agrobacterium-mediated transformation of embryogenic cell suspensions of the banana cultivar Rasthali (AAB). Plant Cell Reports (2001).
  • Hanausek, M, Ganesh, P, Walaszek, Z, Arntzen, Charles, Slaga, T J, Gutterman, J U. Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model. Proc. Natl. Acad. Sci. USA (2001).
  • Haridas, V, Arntzen, Charles, Gutterman, J U. Avicins, a family of triterpenoid saponins from Acacia victoriae (Betham), inhibit activation of nuclear factor-?B by inhibiting both its nuclear localization and ability to bind DNA. Proc. Natl. Acad. Sci. USA (2001).
  • Haridas, V, Higuchi, M, Jayatilake, G S, Bailey, D, Mujoo, K, Blake, M, Arntzen, Charles, Gutterman, J U. Avicins: Triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation. Proc. Natl. Acad. Sci. USA (2001).
  • Kong, Q, Richter, L, Yang, Y #NAME?, Arntzen, Charles, Mason, H S, Thanavala, Y. Oral Immunization with hepatitis B antigen expressed in transgenic plants. Proc. Natl. Acad. Sci. USA (2001).
  • Mor, T S, Sternfeld, M, Soreq, H, Arntzen, Charles, Mason, H S. Expression of recombinant human acetylcholinesterase in transgenic tomato plants. Biotechnology and Bioengineering (2001).

2000

  • Arntzen, Charles. Agricultural biotechnology. SCN News: Nutrition and Agriculture (2000).
  • Arntzen, Charles. Plant-Derived Oral Vaccines: From Concept to Clinical trials. International Seminar on Nuclear War and Planetary Emergencies 25th Session (2000).
  • Arntzen, Charles, Kirk, D D. Vaccination. McGraw-Hill Yearbook of Science & Technology (2000).
  • Bosque-Pérez, N A, May, G D, Arntzen, Charles. Applicability of an Agrobacterium-based system for the transformation of Musa species with diverse genomic constitution and ploidy level. Acta Horticulturae (2000).
  • Richter, L J, Thanavala, Y, Arntzen, Charles, Mason, H S. Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nature Biotechnology (2000).
  • Tacket, C O, Mason, H S, Losonsky, G, Estes, M K, Levine, M M, Arntzen, Charles. Human immune responses to a Novel Norwalk virus vaccine delivered in transgenic potatoes. The Journal of Infectious Diseases (2000).
  • Walmsley, A M, Arntzen, Charles. Plants for delivery of edible vaccines. Current Opinion in Biotechnology (2000).

Selected Publications

2006

  • L Santi, A Giritch, C Roy, S Marillonnet, V Klimyuk, Y Gleba, R Webb, Charles Arntzen, H Mason. Protection conferred by recombinant Yersinia pestis antigens produced by a rapid and highly scalable plant expression system. Proc Natl Acad Sci USA (2006) Refereed Articles.

2005

  • Charles Arntzen, Stanley Plotkin, Betty Dodet. Plant-derived vaccines and antibodies: Potential and Limitations. Vaccine (2005) Refereed Articles.
  • J Bryan, B Maloney, Naokazu Takeda, Yuriko Suzaki, Ami Yasushi, Tian Li, Tatsuo Miyamura, Charles Arntzen, Hugh Mason. Challenges in creating a vaccine to prevent hepatitis E. Vaccine (2005) Refereed Articles.
  • Y Thanavala, M Mahoney, S Pal, A Scott, L Richter, N Natarajan, P Goodwin, Charles Arntzen, H Mason. Immunogenicity in humans of an edible vaccine for hepatitis B. Proc. Natl. Acad. Sci., U.S (2005) Refereed Articles.
  • Z Huang, L Santi, K LePore, J Kilbourne, Charles Arntzen, H Mason. Rapid, high-level production of hepatitis B core antigen in plant leaf and its immunogenicity in mice. Vaccine (2005) Refereed Articles.

2004

  • Levine, M M, Rappuoli, R, Liu, M A, Good, M F, Mor, T S (Author) ,Mason, H S (Author) ,Kirk, D D (Author) ,Arntzen, Charles (Author) ,Cardineau, G A (Author). New Generation Vaccines. Plants as Production and Delivery Vehicle for Orally Delivered Subunit Vaccines (2004) Book Chapters.
  • M Rigano, M Alvarez, J Pinkhasov, Y Jin, F Sala, Charles Arntzen, A Walmsley. Production of a fusion protein consisting of the enterotoxigenic Escherichia coli heat-labile toxin B subunit and a tuberculosis antigen in Arabadopsis thaliana. Plant Cell Rep (2004) Refereed Articles.
  • McGhee, J R, Mestecky, J F, Mason, H S (Author) ,Chikwamba, R (Author) ,Santi, L (Author) ,Mahoney, R T (Author) ,Arntzen, Charles (Author). Mucosal Immunology. Antigen delivery systems: Transgenic plants for mucosal vaccines (2004) Book Chapters.
  • N Matoba, A Magerus, B Geyer, Y Zhang, M Muralidharan, A Alfsen, Charles Arntzen, M Bomsel, T Mor. A mucosally targeted subunit vaccine candidate eliciting HIV-1 transcytosis-blocking Abs. Proc Natl Acad Sci USA (2004) Refereed Articles.
  • R Peterson, Charles Arntzen. On risk and plant-based pharmaceuticals. TRENDS in Biotechnology (2004) Refereed Articles.

2003

  • A Walmsley, Charles Arntzen. Plant cell factories and mucosal vaccines. Current Opinions in Biotechnology (2003) Refereed Articles.
  • A Walmsley, M Alvarez, Y Jin, D Kirk, S Lee, J Pinkhasov, M Rigano, Charles Arntzen, H Mason. Expression of the B subunit of Escherichia coli heat-labile enterotoxin as a fusion protein in transgenic tomato. Plant Cell Rep (2003) Refereed Articles.
  • Arntzen, Charles, Pitman, S. Biotechnology. Encyclopedia of Food and Culture (2003) Encyclopedia Articles.
  • Charles Arntzen, A Coglan, B Johnson, J Peacock, M Rodemeyer. GM Crops: Science, Politics and Communication. Nature Reviews Genetics (2003) Refereed Articles.
  • M Rigano, F Sala, Charles Arntzen, A Walmsley. Targeting of plant-derived vaccine antigens to immunoresponsive mucosal sites. Vaccine (2003) Refereed Articles.
  • M Smith, L Ricther, Charles Arntzen, M Shuler, H Mason. Structral characterization of plant-derived hepatitis B surface antigen employed in oral immunization studies. Vaccine (2003) Refereed Articles.

2002

  • H Mason, H Warzecha, T Mor, Charles Arntzen. Edible plant vaccines: applications for prophylactic and therapeutic molecular medicine. TRENDS in Molecular Medicine (2002) Refereed Articles.
  • T Ganapathi, V Haridas, J Gutterman, Charles Arntzen. Metabolomics of plant saponins; Bioprospecting triterpene glycoside diversity with respect to mammalian cell targets. OMICS: Journal of Integrative Biology (2002) Refereed Articles.

2001

  • Charles Arntzen. Agricultural biotechnology. J. Sci. Food Agric (2001) Refereed Articles.
  • Charles Arntzen, I Chalmers. The risks and rewards of biotechnology. Gastronomica (2001) Nonrefereed Articles.
  • M Hanausek, P Ganesh, Z Walaszek, Charles Arntzen, T Slaga, J Gutterman. Avicins, a family of triterpenoid saponins from Acacia victoriae (Bentham), suppress H-ras mutations and aneuploidy in a murine skin carcinogenesis model. Proc. Natl. Acad. Sci. USA (2001) Refereed Articles.
  • Q Kong, L Richter, Y Yang, Charles Arntzen, H Mason, Y Thanavala. Oral Immunization with hepatitis B antigen expressed in transgenic plants. Proc. Natl. Acad. Sci. USA (2001) Refereed Articles.
  • T Ganapathi, N Higgs, P Balint-Kurti, Charles Arntzen, G May, J Van Eck. Agrobacterium-mediated transformation of embryogenic cell suspensions of the banana cultivar Rasthali (AAB). Plant Cell Reports (2001) Refereed Articles.
  • T Mor, M Sternfeld, H Soreq, Charles Arntzen, H Mason. Expression of recombinant human acetylcholinesterase in transgenic tomato plants. Biotechnology and Bioengineering (2001) Refereed Articles.
  • V Haridas, Charles Arntzen, J Gutterman. Avicins, a family of triterpenoid saponins from Acacia victoriae (Betham), inhibit activation of nuclear factor-B by inhibiting both its nuclear localization and ability to bind DNA. Proc. Natl. Acad. Sci. USA (2001) Refereed Articles.
  • V Haridas, M Higuchi, G Jayatilake, D Bailey, K Mujoo, M Blake, Charles Arntzen, J Gutterman. Avicins: Triterpenoid saponins from Acacia victoriae (Bentham) induce apoptosis by mitochondrial perturbation. Proc. Natl. Acad. Sci. USA (2001) Refereed Articles.

2000

  • A Walmsley, Charles Arntzen. Plants for delivery of edible vaccines. Current Opinion in Biotechnology (2000) Refereed Articles.
  • Arntzen, Charles. McGraw-Hill Yearbook of Science & Technology. Vaccination (2000) Book Chapters.
  • C Tacket, H Mason, G Losonsky, M Estes, M Levine, Charles Arntzen. Human immune responses to a Novel Norwalk virus vaccine delivered in transgenic potatoes. The Journal of Infectious Diseases (2000) Refereed Articles.
  • Charles Arntzen. Agricultural biotechnology. SCN News: Nutrition and Agriculture (2000) Nonrefereed Articles.
  • Charles Arntzen. Plant-Derived Oral Vaccines: From Concept to Clinical trials In: International Seminar on Nuclear War and Planetary Emergencies 25th Session. World Scientific Publishing Co,Singapore (2000) Refereed Articles.
  • Charles Arntzen, D Kirk. Vaccination. McGraw-Hill Yearbook of Science & Technology (2000) Nonrefereed Articles.
  • L Richter, Y Thanavala, Charles Arntzen, H Mason. Production of hepatitis B surface antigen in transgenic plants for oral immunization. Nature Biotechnology (2000) Refereed Articles.
  • N Bosque-Pérez, G May, Charles Arntzen. Applicability of an Agrobacterium-based system for the transformation of Musa species with diverse genomic constitution and ploidy level. Acta Horticulturae (2000) Refereed Articles.