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Biodesign Directory Profile

Contact Information

(480)727-7520

Cheryl Nickerson, PhD

Professor

The Biodesign Institute, Infectious Diseases and Vaccinology

Selected Publications

2013

  • Crabb?, A., Nielsen-Press, S., Woolley, Barrila, J., Buchanan, K., McCracken, J., Ott, M., Nelman-Gonzalez, M., Pierson, D., Wilson, J.W., Stefanyshyn-Piper, H.M., and C.A. Nickerson. Spaceflight enhances aggregation and random budding in Candida albicans. PLoS ONE (2013) Refereed Articles.
  • M. Herbst-Kralovetz, A.L. Radtke, M.K. Lay, B.E. Hjelm, A.N. Bolick, S.S. Sarker, R.L. Atmar, D.H. Kingsley, C.J. Arntzen, M.K. Estes, and C.A. Nickerson. 2013. Correlation between lack of norovirus replication and histo-blood group antigen expression i. Correlation between lack of norovirus replication and histo-blood group antigen expression in three-dimensional INT-407 intestinal epithelial cell cultures. Emerging Infectious Diseases (2013) Refereed Articles.

2012

  • De Weirdt, R., Crabb?, A., Roos, S., Vollenweider, S., Lacroix, C., van Pijkeren, J.P., Britton, R.A., Sarker, S., Van de Wiele, T., and C.A. Nickerson. .. Glycerol supplementation enhances Lactobacillus reuteris protective effect against colonization by Salmonella enterica serovar Typhimurium in a three-dimensional model of colonic epithelium.. PLoS ONE (2012) Refereed Articles.
  • M. Mellata, S. Sarker, C.A. Nickerson, J. Maddux, and R. Curtiss III. New insights into the bacterial fitness-associated mechanisms revealed by the characterization of large plasmids of an avian pathogenic E. coli.. PLoS ONE (2012) Refereed Articles.

2011

  • A. Crabb?, S. Sarker, R.V. Houdt, C.M. Ott, N. Leys, P. Cornelis and C.A. Nickerson. Alveolar epithelium protects macrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model.. Cellular Microbiology (2011) Refereed Articles.
  • Castro S.L., Nelman-Gonzalez M., Nickerson C.A., Ott, C.M.. Low fluid shear culture of Staphylococcus aureus induces attachment-independent biofilm formation and represses hfq expression. Environ Microbiol (2011) Refereed Articles.
  • Crabb?, A., Schurr, M., Schurr, J., Wilson, J.W., Tsaprailis, R. Bober, J. Devich, A. Ruggles, G, Stefanyshyn-Piper, H.M., and C.A. Nickerson. Transcriptional and proteomic responses of Pseudomonas aeruginosa PAO1 to spaceflight conditions involve Hfq regulation and reveal a role for oxygen. Appl. Environ. Microbiol. (2011) Refereed Articles.
  • Crabbe, A., Schurr, M., Schurr, J., Wilson, J.W., Tsaprailis, R. Bober, J. Devich, A. Ruggles, G, Stefanyshyn-Piper, H.M., and C.A. Nickerson. Hfq is an evolutionarily conserved spaceflight response regulator in Pseudomonas aeruginosa.. Appl. Environ. Microbiol. (2011) Refereed Articles.
  • Ed. Alexander Chouker, Ott, C.M., Crabbe, A., Wilson, J.W., Barrila, J.B, and C.A. Nickerson. Stress Challenges and Immunity in Space. Effect of spaceflight on microbial gene expression and virulence (2011) Book Chapters.
  • Jennings M.E., Quick L.N., Soni A., Davis R.R., Crosby K, Ott C.M., Nickerson CA., and J.W. Wilson. Characterization of the Salmonella enterica serovar Typhimurium ydcI gene which encodes a conserved DNA binding protein required for full acid stress resistance. J. Bacteriol (2011) Refereed Articles.
  • Nickerson, C.A., V.M. Garcia, T.L. Molina, S.L. Castro, C.M. Ott, J. Briggler, A.L. Pitt, J.K. Byram, and M.A. Nickerson. Evaluation of Microorganisms Cultured from Injured and Repressed Tissue Regeneration Sites in Endangered Giant Aquatic Ozark Hellbender Salamanders. PLoS ONE. 2011;6(12):e28906. Epub 2011 Dec 19. (2011) Refereed Articles.
  • Ott, C.M., Crabbe, A., Wilson, J.W., Barrila, J.B, and C.A. Nickerson. Effect of spaceflight on microbial gene expression and virulence, in Stress Challenges and Immunity in Space, Ed. Alexander Chouker. 2011.. (2011) Authored Books.

2010

  • A. Crabb?, S. Sarker, R.V. Houdt, C.M. Ott, N. Leys, P. Cornelis and C.A. Nickerson. Alveolar epithelium protects macrophages from quorum sensing-induced cytotoxicity in a three-dimensional co-culture model. Cellular Microbiology (2010) Refereed Articles.
  • Crabbe, A., Pyke, B., Monsierus, P., Van Houdt, R., Nickerson, C.A., Leys, N., and P. Cornelis. Response of Pseudomonas aeruginosa to low shear modeled microgravity involves AlgU regulation. Environ. Microbiol. (2010) Refereed Articles.
  • Crabbe, A., Pyke, B., Monsierus, P., Van Houdt, R., Nickerson, C.A., Leys, N., and P. Cornelis. Response of Pseudomonas aeruginosa to low shear modeled microgravity involves AlgU regulation. Environ. Microbiol (2010) Refereed Articles.
  • Hjelm, B., A.N. Berta, C.A. Nickerson, C.J. Arntzen, and M.M. Herbst-Kralovetz. Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model. Biology of Reproduction (2010) Refereed Articles.
  • L.E. OSullivan, C.A. Nickerson, and J.W. Wilson. A series of IncQ-based reporter plasmids for use in a range of Gram negative genera. Journal of Microbiology and Biotechnology (2010) Refereed Articles.
  • L.E. OSullivan, C.A. Nickerson, and J.W. Wilson. A series of IncQ-based reporter plasmids for use in a range of Gram negative genera. Journal of Microbiology and Biotechnology May;20(5):871-4. (2010) Refereed Articles.
  • Radtke, A., Wilson, J.W., Sarker, S., and C.A. Nickerson. 2010. Radtke, A., Wilson, J.W., Sarker, S., and C.A. Nickerson .. Analysis of interactions of Salmonella type three secretion mutants with 3-D intestinal epithelial cells. PLoS ONE (2010) Refereed Articles.
  • Skardal, A., S. Sarker, A. Crabb?, C.A. Nickerson, G.D. Prestwich. The Generation of 3-D Tissue Models based on Hyaluronan Hydrogel-Coated Microcarriers within a Rotating Wall Vessel Bioreactor. Biomaterials (2010) Refereed Articles.

2009

  • Hjelm, B., A.N. Berta, C.A. Nickerson, C.J. Arntzen, and M.M. Herbst-Kralovetz. Development and characterization of a three-dimensional organotypic human vaginal epithelial cell model. Biology of Reproduction (2009) Refereed Articles.
  • La Belle, J.T., Shah, M., Reed, J., Nandakumar, V., Alford, T.L., Wilson, J.W., Nickerson, C.A., and Joshi, L.. A novel sensor for rapid and ultra-low level detection of Salmonella enterica Serovar Typhimurium. Electroanalysis (2009) Refereed Articles.

2008

  • J.W. Wilson, C.M. Ott, L. Quick, R. Davis, E. Richter, S. Sarker, A. Crabbe, M. Porter, K. H?ner zu Bentrup, R. Ramamurthy, G. Tsaprailis, M. Shah, M. Nelman-Gonzalez, R. Bober, J. Devich, A. Ruggles, J. Barrila, Benjamin, J., C. Goulart, M. Rupert, L. St. Media ion content inhibits spaceflight-induced increases in microbial virulence. PLoS ONE (2008) Refereed Articles.
  • T.A. Myers, C.A. Nickerson, D. Kaushal, C.M. Ott, K. Honer zu Bentrup, R. Ramamurthy, M. Nelman-Gonzales, D.L. Pierson, M.T. Philipp. Closing the Phenotypic Gap between Transformed Neuronal Cell Lines in Culture and Untransformed Neurons. Journal of Neuroscience Methods (2008) Refereed Articles.
  • W Cody, J Wilson, D Hendrixson, K McIver, K Hagman, C Ott, Cheryl Nickerson, M Schurr. Skim mild enhances the viability of frozen bacterial stocks. Journal of Microbiol Methods (2008) Refereed Articles.

2007

  • Cheryl Nickerson. First Report of In Vitro Infection of a 3-Dimensional Organoid Model of Human Small Intestinal Epithelium with Human Noroviruses. Emerging Infectious Diseases (2007) Refereed Articles.
  • Cheryl Nickerson. Spaceflight alters bacterial gene expression and virulence and reveals role for global regulator Hfq. Proc. Natl. Acad. Sci. USA (2007) Refereed Articles.
  • Cheryl Nickerson, Clint Coleman, Cheryl Nickerson. Cloning and transfer of the Salmonella SPI-2 type III secretion system for studies in a range of Gram negative genera. Applied and Environmental Microbiology (2007) Refereed Articles.
  • Cheryl Nickerson, Emily Richter, Mark Ott. Studying host-pathogen interactions in 3-D: Organotypic models for infectious disease and drug development. Journal of Neuroimmune Pharmacology (2007) Refereed Articles.
  • Cheryl Nickerson, Soo-Young Wanda, Cheryl Nickerson, Roy Curtiss. Role of RpoS in fine-tuning the synthesis of Vi capsular polysaccharide in Salmonella enterica serotype Typhi. Infection and Immunity (2007) Refereed Articles.
  • E Nauman, C Ott, E Saunders, D Tucker, D Pierson, J Wilson, Cheryl Nickerson. A Novel Quantitative Biosystem to Model Physiological Fluid Shear Stress on Cells. Appl. Environ. Microbiol (2007) Refereed Articles.
  • Santander, J.M, Wanda, S.Y., Nickerson, C.A., and R. Curtiss III. Role of RpoS in fine-tuning the synthesis of Vi capsular polysaccharide in Salmonella enterica serotype Typhi. Infect Immun. (2007) Refereed Articles.

2006

  • Abraham Eisenstark, J.W. Wilson and C.A. Nickerson. Methods in Molecular Biology. In-vivo excision, cloning and broad-host-range transfer of large bacterial DNA segments using VEX-Capture (2006) Book Chapters.
  • C.A. Nickerson and M.J. Schurr, C. Coleman, C. Baker, and C.A. Nickerson. Molecular Paradigms of Infectious Disease: A Bacterial Perspective. The Role of Sigma Factors in Regulating Bacterial Stress Responses and Pathogenesis (2006) Book Chapters.
  • Cheryl Nickerson, E Richter, C Ott. Studying host-pathogen interactions in 3-D: Organotypic models for infectious disease and drug development. Journal of Neuroimmune Pharmacology (2006) Refereed Articles.
  • J Santander, S Wanda, Cheryl Nickerson, R Curtiss. Role of RpoS in fine-tuning the synthesis of Vi capsular polysaccharide in Salmonella enterica serotype Typhi. (2006) Nonrefereed Articles.
  • J Wilson, Cheryl Nickerson. A new experimental approach for studying bacterial genomic island evolution identifies island genes with bacterial host-specific expression patterns. BMC Evol Biol (2006) Refereed Articles.
  • K Honer zu Bentrup, S Alexander, N Pellis, K Buchanan, Cheryl Nickerson, R Ramamurthy, M Ott, K Emami, M Nelman-Gonzalez, J Wilson, E Richter, T Goodwin, D Pierson. 3-D organotypic models of human colonic epithelium to study the early stages of enteric salmonellosis. Microbes and Infection (2006) Refereed Articles.
  • K Johanson, K Muse, J Freeman, L Stodieck, T Hammond, P Allen, A Gonzalez-Villalobos, J Nesbitt, Cheryl Nickerson, K Honer zu Bentrup, J Wilson, R Ramamurthy, R D'Elia. Haploid deletion strains of Saccharomyces cerevisiae that determine survival during spaceflight. Acta Astronautica (2006) Refereed Articles.
  • Nickerson, C.A. and Schurr, M.J. (Eds). Molecular Paradigms of Infectious Disease: A Bacterial Perspective. (2006) Authored Books.
  • Nickerson, Cheryl, Schurr, M J. Molecular Paradigms of Infectious Disease: A Bacterial Perspective. (2006) Edited Books.
  • T Straub, M Abbaszdegan, Cheryl Nickerson, K Höner zu Bentrup, B Mayer, R Bartholomew, C Valdez, C Bruckner-Lea, A Dohnalkova, P Orosz Coghlan, C Gerba. First Report of In Vitro Infection of a 3-Dimensional Organoid Model of Human Small Intestinal Epithelium with Human Noroviruses. Emerging Infectious Diseases (2006) Refereed Articles.

2005

  • A Carterson, K Honer zu Bentrup, C Ott, M Clarke, C Vanderburg, K Buchanan, D Pierson, Cheryl Nickerson, M Schurr. A549 lung epithelial cells grown as 3-D aggregates: Alternative tissue culture model for P. aeruginosa pathogenesis. Infect Immun (2005) Refereed Articles.
  • H LaMarca, C Ott, K Höner zu Bentrup, C LeBlanc, D Pierson, Cheryl Nickerson, A Nelson, C Morris. A Novel Three-Dimensional Model of Human Placentation for the Study of Human Cytomegalovirus Pathogenesis. Placenta (2005) Refereed Articles.
  • J Wilson, Cheryl Nickerson. Cloning of a functional Salmonella SPI-I type III secretion system and development of a method to create mutations and epitope fusions in the cloned genes. Journal of Biotechnology (2005) Refereed Articles.
  • R D'Elia, P Allen, K Johanson, Cheryl Nickerson, T Hammond. Homozygous diploid deletion strains of Saccharomyces cerevisiae that determine lag phase and dehydration survival. Applied Microbiology and Biotechnology (2005) Refereed Articles.
  • R D'Elia, P Allen, K Johanson, Cheryl Nickerson, T Hammond. Homozygous diploid deletion strains of Saccharomyces cerevisiae that determine lag phase and dehydration tolerance. Appl Microbiol Biotech (2005) Refereed Articles.

2004

  • J Wilson, D Figurski, Cheryl Nickerson. VEX-capture: A new technique that allows in-vivo excision, cloning, and broad-host-range transfer of large bacterial genomic DNA segments. J. Microbiol. Methods (2004) Refereed Articles.

2002

  • J Wilson, R Ramamurthy, C Ott, S Porwollik, M McClelland, D Pierson, Cheryl Nickerson. Low shear modeled microgravity alters the Salmonella typhimurium response in an RpoS-independent manner. Appl. Environ. Microbiol (2002) Refereed Articles.
  • J Wilson, R Ramamurthy, S Porwollik, M McClelland, T Hammond, P Allen, C Ott, D Pierson, Cheryl Nickerson. Microarray analysis identifies Salmonella genes belonging to the low-shear modeled microgravity regulon. Proc. Natl. Acad. Sci. USA (2002) Refereed Articles.

2001

  • Cheryl Nickerson. Putting C. elegans to Gram positive use. Trends Microbiol (2001) Refereed Articles.
  • Cheryl Nickerson. Altered gene expression in response to Bordetella pertussis infection. Trends Microbiol (2001) Refereed Articles.
  • Cheryl Nickerson, T Hammond, D Pierson, T Goodwin, J Terlonge, C Ott, K Buchanan, W Uicker, K Emami, C Cedor, R Ramamurthy. Three-Dimensional Tissue Assemblies: Novel Models for the Study of Salmonella enterica Serovar Typhimurium Pathogenesis. Infect. Immun (2001) Refereed Articles.
  • P Brown, C Dozios, Cheryl Nickerson, J Terlonge, A Zuppardo, R Curtiss. A novel positive regulator of curli synthesis in an avian pathogenic Escherichia coli strain. Mol. Microbiol (2001) Refereed Articles.

2000

  • Cheryl Nickerson. Macrophage-specific fimbriae. Trends Microbiol (2000) Refereed Articles.
  • Cheryl Nickerson. Stomach Islands. Trends Microbiol (2000) Refereed Articles.
  • Cheryl Nickerson. Understanding TB persistence. Trends Microbiol (2000) Refereed Articles.
  • Cheryl Nickerson, M Ott, S Mister, B Morrow, L Burns-Keliher, D Pierson. Microgravity as a novel environmental signal affecting Salmonella enterica serovar Typhimurium virulence. Infect. Immun (2000) Refereed Articles.