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Contact Information

(480)965-4691

Stuart Lindsay, PhD Regents Professor

Director

The Biodesign Institute, Single Molecule Biophysics

Professor

College of Liberal Arts and Sciences, Physics

Professor

College of Liberal Arts and Sciences, Chemistry and Biochemistry

Bio

Regents Professor, Department of Physics and Department of Chemistry and Biochemistry, College of Liberal Arts and Sciences

Office: DBA 120E
Phone: 480-965-4691
Fax: 480-965-2747

Education

Ph.D., University of Manchester, U.K., 1976

Research Areas

Biophysics, Nanoscience

Link to Lab Home Page

Research and Teaching Interests

Stuart Lindsay, Ph.D., specializes in biophysics at the molecular level and scanning probe microscopy. Much of his work is aimed at speedier diagnosis and an understanding of the molecular basis of disease. He holds 29 US patents and is a technology advisor for the Atomic Force Microscope Division of Agilent Technologies. Agilent has acquired Molecular Imaging Corporation, which he co-founded in 1993.

Dr. Lindsay's lab conducts innovative research in biological physics, molecular electronics, solar energy and condensed matter physics. The Lindsay Lab researchers are interested in how genes work, and study the way in which proteins change DNA structure to switch genes on and off. They are also interested in the chemistry and physics of the liquid-solid interface, and are trying to understand electrochemical and charge transfer processes at the single-molecule level. One project that Dr. Lindsay is pursuing is a new method of DNA sequencing to allow much faster and cheaper sequencing of individual human genomes. His radical approach involves electron tunneling through electrodes funtionalized with molecules that recognize the DNA bases.

His 29 patents cover mostly technology for atomic force microscopy and new devices based on molecular electronics.  After receiving his PhD in Physics from the University of Manchester, Dr. Lindsay spent two years as a consultant at Philips Industries in London before joining the faculty at ASU. He has been at ASU for 30 years. His body of published work comprises over 200 articles in peer-reviewed journals.  He is the author of the first comprehensive text for nanoscience, "Introduction to Nanoscience" (OUP, 2009). Dr. Lindsay sits on the editorial boards of Biophysical Journal and AIP Press International Series in Basic and Applied Biological Physics. He also holds the position of Associate Editor for Probe Microscopy at Ultramicroscopy. He is a fellow of the American Association for the Advancement of Science and the American Physical Society.

Selected Publications

1. “Tunneling readout of hydrogen-bonding based recognition”  Chang, S., He, J., Kibel, A., Lee, M., Sankey, O. F., Zhang, P. & Lindsay, S. M. Nature Nanotechnology 4, 297-301 (2009). 

2. "A Molecular Switch Based on Potential-Induced Changes of Oxidation State," F. Chen, J. He, C. Nuckolls, T. Roberts, J.E. Klare and S. Lindsay, Nano Letters 5, 503-506 (2005).

3. “Reproducible Measurement of Single-Molecule Conductivity” X. D. Cui, A. Primak, X. Zarate, J. Tomfohr, O. F. Sankey, A. L. Moore, T. A. Moore, D. Gust, G. Harris and S. M. Lindsay, Science 294, 571-574 (2001).

4. Single-molecule recognition imaging microscopy,  C. Stroh, H. Wang, R. Bash, B. Ashcroft, J. Nelson, H. Gruber, D. Lohr, S. M. Lindsay, and P. Hinterdorfer, Proc. Natl. Acad. Sci (USA)., 101 12503–12507 (2004).

5. “Self-Assembled Water-Soluble Nucleic Acid Probe Tiles for Label-Free RNA Hybridization Assays”  Yonggang Ke, Stuart Lindsay, Yung Chang, Yan Liu, Hao Yan, Science 319 180-183 (2008). 

Selected Publications

2007

  • Chhabra, Rahul , Sharma, Jaswinder, Ke, Yonggang, Liu, Yan, Rinker, Sherri, Lindsay, Stuart, Yan, Hao. Spatially addressable multiprotein nanoarrays templated by aptamer-tagged DNA nanoarchitectures. Journal of American Chemical Society (Communication) (2007).
  • Dalal, Yamini, Wang, Hongda, Lindsay, Stuart, Henikoff, Steven. Tetrameric Structure of Centromeric Nucleosomes in Interphase Drosophila Cells. Public Library of Science, Biology (2007).
  • He, Jin, Chen, Fan , Lindsay, Stuart, Nuckolls, Colin. “Length dependence of charge transport in oligoanilines. Applied Physics Letters (2007).
  • He, Jin, Lin, Lisha, Zhang, Peiming , Lindsay, Stuart. Identification of DNA base-pairing via tunnel current decay. Nano Lertters (2007).
  • Lin, LiYun, Hom, Doris, Lindsay, Stuart, Chaput, John. In Vitro Selection of Histone H4 Aptamers for Recognition Imaging Microscopy. Journal of American Chemical Society (Communication) (2007).
  • Lindsay, Stuart. Chromatin Control of Gene Expression: The Simplest Model. Biophysical Journal (2007).
  • Lindsay, Stuart, Lohr, Dennis, Bash, Ralph C, Wang, Hongda , Yodh, Jaya. Using atomic force microscopy to study chromatin structure and nucleosome remodeling. Methods 2007 (2007).
  • Lindsay, Stuart, Ratner, M A. Molecular Transport Junctions: Clearing Mists. Advanced Materials (2007).
  • Lindsay, Stuart, Ratner, M A. Molecular Transport Junctions: Clearing Mists. Advanced Materials (2007).
  • Morito, Tomoyuki , Lindsay, Stuart. Determination of Single Molecule Conductances of Alkanedithiols by Conducting-Atomic Force Microscopy with Large Gold Nanoparticles. Journal of American Chemistry communication (2007).
  • Solis, Francisco Javier, Bash, Ralph C, Wang, Hongda, Yodh, J. , Lindsay, Stuart, Lohr, Dennis Evan. Effects of Histone Acetylation on Properties of Nucleosomes in MMTV and 5S Arrays. Biochemistry (2007).

2006

  • Bash, R, Wang, H, Anderson, C, Yodh, J, Hager, G, Lindsay, Stuart, Lohr, D. AFM imaging of protein movements: Histone H2A-H2B release during nucleosome remodeling. Letters (2006).
  • Bash, R, Wang, H, Anderson, C, Yodh, J, Hager, G, Lindsay, Stuart, Lohr, D. AFM imaging of protein movements: Histone H2A-H2B release during nucleosome remodeling. FEBS Letters (2006).
  • Chen, F, Nuckolls, C, Lindsay, Stuart. In situ measurements of oligoaniline conductance: Linking electrochemistry and molecular electronics. Chemical Physics (2006).
  • Chen, F, Nuckolls, C, Lindsay, Stuart. In situ measurements of oligoaniline conductance: Linking electrochemistry and molecular electronics. Chemical Physics (2006).
  • He, J, Fu, Q, Lindsay, Stuart, Ciszek, J W, Tour, J M. Electrochemical Origin of Voltage-Controlled Molecular Conductance Switching. J. Am. Chem. Soc (2006).
  • He, Jin, Sankey, Otto F, Myeong, Lee, Nongjian, Tao, Li, Xiulan, Lindsay, Stuart. Measuring single molecule conductance with break junctions. Faraday Discussions (2006).
  • Li, X, He, J, Hihath, J, Xu, B, Lindsay, Stuart, Tao, N. Conductance of Single Alkanedithiols: Conduction Mechanism and Effect of Molefule-Electrode Contacts. Am. Chem. Society (2006).
  • Li, X, He, J, Hihath, J, Xu, B, Lindsay, Stuart, Tao, N. Conductance of Single Alkanedithiols: Conduction Mechanism and Effect of Molecule-Electrode Contacts. J. Am. Chem. Soc (2006).
  • Lin, L, Wang, H, Liu, Y, Yan, H, Lindsay, Stuart. Recognition Imaging with a DNA Aptamer. Biophys. J (2006).
  • Lin, L, Wang, H, Liu, Y, Yan, H, Lindsay, Stuart. Recognition Imaging with a DNA Aptamer. Biophys. J (2006).
  • Lindsay, Stuart. Molecular Wires and Devices: Advances and Issues. Faraday Discussions (2006).
  • Lindsay, Stuart. Molecular Wires and Devices: Advances and Issues. Faraday Discussions (2006).
  • Marcus, W D, Lindsay, Stuart, Sierks, M R. Identification and repair of positive binding anitibodies containing randomly generated amber codons from synthetic phage display libraries. Biotechnology Progress (2006).
  • Marcus, W D, Lindsay, Stuart, Sierks, M R. Identification and repair of positive binding antibodies containing randomly generated amber codons from synthetic phage display libraries. Biotechnology Progress (2006).
  • Marcus, W D, Wang, H, Lohr, D, Sierks, M R, Lindsay, Stuart. Isolation of an scFv targeting BRG1 using phage display with characterization by AFM. Biochemical and Biophysical Research Communications (2006).
  • Visoly-Fisher, I, Daie, K, Terazono, Y, Herrero, C, Fungo, F, Otero, L, Durantini, E, Silber, J J, Sereno, L, Gust, D, Moore, T A, Moore, A L, Lindsay, Stuart. Conductance of a biomolecular wire. Proc. Nat. Acad. Sci (2006).
  • Visoly-Fisher, I, Daie, K, Terazono, Y, Herrero, C, Fungo, F, Otero, L, Durantini, E, Silber, J J, Sereno, L, Gust, D, Moore, T A, Moore, A L, Lindsay, Stuart. Conductance of a biomolecular wire. Proc. Nat. Acad. Sci (2006).
  • Xiao, Xiaoyin, Brune, Daniel, Jin, He, Lindsay, Stuart, Gorman, Christopher B, Nongjian, Tao. Redox-gated electron transport in electrically wired ferrocene molecules. Chemical Physics (2006).

2005

  • Chen, Fan, Je, Jin, Nuckolls, Colin, Roberts, Tucker, Klare, Jennifer E, Lindsay, Stuart. A Molecular Switch Based on Potential-Induced Changes of Oxidation State. Nano Letters (2005).
  • Ebner, A, Kienberger, F, Kada, G, Stroh, C M, Geretschlager, M, Kamruzzahan, A S M, Wildling, L, Johnson, W T, Ashcroft, B, Nelson, J, Lindsay, Stuart, Gruber, H J, Hinterdorfer, P. Localization of Single Avidin-Biotin Interactions Using Simultaneous Topography and Molecular Recognition Imaging. Chem. Phys. Chem (2005).
  • He, J, Chen, F, Sankey, O F, Terazono, Y, Herrero, C, Gust, D, Moore, T A, Moore, A L, Lindsay, Stuart. Electronic Decay Constant of Carotenoid Polyenes from Single-Molecule Measurements. J. Am. Chem.Soc (2005).
  • He, J, Lindsay, Stuart. On the Mechanism of Negative Differential Resistance in Ferrocenylundecanethiol Self-Assembled Monolayers. J. Am. Chem. Soc. (Communication) (2005).
  • He, Jin, Chen, Fan, Liddell, Paul A, Andreasson, Joakim, Straight, Stephen D, Gust, Devens, Moore, Thomas A, Moore, Ana L, Jun, Li, Sankey, Otto F, Lindsay, Stuart. Switching of a photochromic molecule on gold electrodes; single-molecule measurements. Nanotechnology (2005).
  • Johnson, W T, Kada, G, Stroh, C, Gruber, H, Wang, H, Kienberger, F, Ebner, A, Lindsay, Stuart, Hinterdorfer, P. Simultaneous Topography and RECognition Mapping with PicoTREC: A Powerful new Technology That Can Be Used to Map Nanometer-Scale Molecular Binding Sites On A Variety of Surfaces. NSTI-Nanotech (2005).
  • Lindsay, Stuart. Single-Molecule Electronic Measurements with Metal Electrodes. J. Chem. Ed (2005).
  • Lund, K, Liu, Y, Lindsay, Stuart, Yan, H. Self-assembling molecular pegboard. J. Am. Chem. Soc. (Communication) (2005).
  • Tomfohr, J, Ramachandran, G, Sankey, O F, Lindsay, Stuart. Making Contacts to Single Molecules: Are we there yet?. Introducing Molecular Electronics (2005).
  • Tomfohr, J, Ramachandran, G, Sankey, O F, Lindsay, Stuart. Making Contact to Single Molecules: Are we there yet?. Molecular Electronics (2005).
  • Wang, H, Bash, R, Lindsay, Stuart, Lohr, D. Solution AFM Studies of Human Swi-Snf and Its Interactions with MMTV. Biophysical Journal (2005).

2004

  • Ashcroft, B, Takulapalli, B, Yang, J, Laws, G M, Zhang, H Q, Tao, N J, Lindsay, Stuart, Gust, D, Thornton, T J. Calibration of a pH sensitive buried channel silicon-on-insulator MOSFET for sensor applications. Phys. Stat. Sol (2004).
  • Gomar-Nadal, Elba, Ramachandran, Ganesh K, Chen, Fan, Burgin, Timothy, Veciana, Jaume, Rovira, Concepció, Amabilino, David B, Lindsay, Stuart. Self-Assembled Monolayers of TTF Derivatives on Gold: Characterization and Electron Transport Studies. J. Phys. Chem (2004).
  • Lindsay, Stuart. Interface Single Molecule Electronics. Journal of the Electrochemical Society (2004).
  • Lindsay, Stuart. Single Molecule Electronics. Interface (journal of the Electrochemical Society) (2004).
  • Solis, F J, Bash, R, Yodh, J, Lindsay, Stuart, Lohr, D. A Statistical Thermodynamic Model Applied to Experimental AFM Population and Location Data Is Able to Quantify DNA-Histone Binding Strength and Internucleosomal Interaction Differences between Acetylated and Unacetylated Nucleosomal Arrays. Biophys. J (2004).
  • Stroh, C, Wang, H, Bash, R, Ashcroft, B, Nelson, J, Gruber, H, Lohr, D, Lindsay, Stuart, Hinterdorfer, P. Single-molecule recognition imaging microscopy. Proc. Natl. Acad. Sci (USA) (2004).
  • Wang, H, Bash, R, Yodh, J G, Hager, G, Lindsay, Stuart, Lohr, D. Using Atomic Force Microscopy to Study Nucleosome Remodeling on Individual Nucleosomal Arrays in Situ. Biophysical Journal (2004).

2003

  • Adams, David M, Brus, Louis, Chidsey, Christopher E D, Creager, Stephen, Creutz, Carol, Kagan, Cherie R, Kamat, Prashant V, Lieberman, Marya, Lindsay, Stuart, Marcus, Rudolph A, Metzger, Robert M, Michel-Beyerle, M E, Miller, John R, Newton, Marshall D, R. Charge Transfer on the Nanoscale: Current Status. Journal of Physical Chemistry (2003).
  • Bash, R, Wang, H, Yodh, J G, Hager, G L, Lindsay, Stuart, Lohr, D. Nucleosomal Arrays can be Salt Reconstituted onto a Single Copy MMTV Promoter DNA Template: Their Properties Differ in Several Ways from those of Comparable 5s Concatemeric Arrays. Biochemistry (2003).
  • Hopson, T J, Rawlett, A R, Nagahara, L A, Primak, A, Lindsay, Stuart. A Bond Fluctuation Mechanism for Stochastic Switching in Wired Molecules. Science (2003).
  • Lindsay, Stuart. Biophysics, An Introduction. American Journal of Physics (2003).
  • Lindsay, Stuart. Review of Biophysics, An Introduction American Journal of Physics 2003 2003 . Review of Biophysics, An Introduction (2003).
  • Ramachandran, Ganesh K, Tomfohr, J K, Sankey, O F, Li, Jun, Zarate, X, Primak, A, Terazano, Y, Moore, T A, Moore, A L, Gust, D, Nagahara, L A, Lindsay, Stuart. The Electron Transport Properties of a Carotene Molecule in a Metal-(Single-Molecule)-Metal Junction. Journal of Physical Chemistry (2003).
  • Salomon, A, Cahen, D, Lindsay, Stuart, Tomfohr, J, Engelkes, V B, Frisbie, C D. Comparison of electronic transport measurements on organic molecules. Advanced Materials (2003).

2002

  • Balagurumoorthy, P, Lindsay, Stuart, Harrington, R E. Atomic Force Microscopy Reveals Kinks in the DNA response element DNA. Biophysical Chemistry (2002).
  • Cui, X D, Zarate, X, Tomfohr, J, Primak, A, Moore, A L, Moore, Thomas Andrew, Gust, D, Harris, G, Sankey, O F, Lindsay, Stuart. Making electrical contacts to molecular monolayers. Nanotechnology (2002).
  • Cui, X D, Zarate, X, Tomfohr, J, Primak, A, Moore, Ana L, Moore, Thomas Andrew, Gust, D, Harris, G, Sankey, O F, Lindsay, Stuart. Bias-induced forces in conducting atomic force microscopy and contact charging of organic monolayers. Ultramicroscopy (2002).
  • Cui, X D, Zarate, X, Tomfohr, J, Primak, A, Moore, Ana L, Moore, Thomas Andrew, Gust, D, Harris, G, Sankey, O F, Lindsay, Stuart. Changes in the Electronic Properties of a Molecule when it is wired into a circuit. J. Phys. Chem. B (2002).
  • Lindsay, Stuart. Single Molecule Electronics and Tunneling in Molecules. Jap. J. Appl. Phys (2002).
  • Ramachandran, G K, Nagahara, L A, Tsui, R K, Lindsay, Stuart. Organic Molecules in an electrical circuit: An AFM study of a negative-differential resistance molecule. Proc. MRS (2002).
  • Rawlett, A M, Hopson, T J, Nagahara, L A, Tsui, R K, Ramachandaran, G K, Lindsay, Stuart. Electrical measurements of a dithiolated electronic molecule via conducting atomic force microscopy. Applied Physics Letters (2002).
  • Wang, H, Bash, R, Yodh, J G, Hager, G L, Lohr, D, Lindsay, Stuart. Glutaraldehyde modified mica: A new surface for atomic force microscopy of chromatin. Biophysical J (2002).

2001

  • Cui, X D, Primak, A, Zarate, X, Tomfohr, J, Sankey, Otto F, Moore, Ana L, AMoore, T, Gust, D, Harris, G, Lindsay, Stuart. Reproducible Measurement of Single-Molecule Conductivity. Science (2001).
  • Zhou, H, Zhang, Y, Yang, Z O, Feng, X Z, Lindsay, Stuart, Baalagurumoorthy, P, Harrington, R E. Conformation and Rigidity of DNA Microcircles containing waf1 Response Element for P53 Regulatory Protein. J. Mol. Biol (2001).

2000

  • Feng, X Z, Bash, R, Balagurumoorthy, P, Lohr, D, Harrington, R E, Lindsay, Stuart. Conformational transition in DNA on a cold surface. Nucleic Acids Res 15 (2000).
  • Leuba, S H, Karymov, M A, Liu, Y Z, Lindsay, Stuart, Zlatanova, J. Mechanically stretching single chromatin fibers. Gene Therapy and Molecular Biology (2000).
  • Leuba, S H, Zlatanova, J, Karymov, M A, Bash, R, Liu, Y Z, Lohr, Dennis Evan, Harrington, R E, Lindsay, Stuart. The mechanical properties of single chromatin fibers under tension. Single Molecules (2000).
  • Lindsay, Stuart. The Scanning Probe Microscope in Biology. Scanning Probe Microscopy, techniques and Applications (2000).
  • Zlatanova, J, Lindsay, Stuart, Leuba, S H. Single molecule force spectroscopy in biology using the atomic force microscope. Prog. Biophys. Mol. Bio (2000).