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Biodesign Directory Profile

Contact Information

480-965-0434

Timothy Karr, PhD

Associate Professor Research

The Biodesign Institute, Infectious Diseases and Vaccinology

Associate Professor Research

The Biodesign Institute, Evolutionary Medicine and Informatics

Bio

Timothy Karr received his PhD in Chemistry in 1981 at the University of California, Santa Barbara.  Dr. Karr was a Jane Coffin Child Postdoctoral Fellow with Bruce Alberts (1981-84) and a American Cancer Society Fellow (1984-87) with Thomas Kornberg in the Department of Biochemistry and Biophysics, UC San Francisco where he began his work on fertilization and early Drosophila embryogenesis.  Subsequently at the University of Illinios, Urbana and The University of Chicago (1987-2002), Dr. Karr continued studies of fertilization and and sperm biology in Drosophila.  In 2002 Dr. Karr received a prestigious Wolfson-Royal Society Merit Award and moved to the University of Bath, United Kingdom, as a Reader in Biology.  In 2006 and 2010, Dr. Karr published the first functional genomic and evolutionary analyses of the Drosophila and mouse sperm proteomes.  In 2008 he moved to the Biodesign Institute at Arizona State University where he continues to elucidate the functional genomics and biochemistry of the mammalian sperm proteomes.

 

Dr. Karr has also pioneered studes into the biology of Wolbachia in Drosophila.  Wolbachia, an obligate intracellular microbe, affects sperm function in infected males leading to a unique form of male paternal effect known as "Cytoplasmic Incompatibility" (CI).  Dr. Karr studies Wolbachia to identify, and then exploit, the molecular mechanism of CI to develop rational strategies for the biocontrol of insect pest populations.

Selected Publications

2013

  • Skerget, S., Rosenow, M., Polpitiya, A., Petritis, K., Dorus, S. and Karr, T.L.. Dynamics of Sperm Maturation in the Mouse Epididymus.. Mol Cellular Proteomics (2013) Refereed Articles.
  • Skerget, S., Rosenow, M., Polpitiya, A., Petritis, K., Dorus, S. and Karr, T.L.. The Rhesus Macaque (Macaca mulatta) Sperm Proteome. Mol Cell Proteomics (2013) Refereed Articles.

2012

  • Dorus, S., Skerget, S. and Karr, T.L.. Proteomic discovery of diverse immunity molecules in mammalian spermatozoa. Systems Biology in Reproductive Medicine (2012) Refereed Articles.
  • Fischer, B. E., Wasbrough, E., Meadows, L. A., Randlet, O., Dorus, S., Karr, T. L., and Russell, S.. Conserved properties of Drosophila and human spermatozoal mRNA repertoires.. Proc Biol Sci (2012) Refereed Articles.
  • Fischer, B.E., Wasbrough, E., Meadows, L.A., Randlet, O., Dorus, S., Karr, T.L., and Russell, S.. Conserved Properties of Drosophila and Human Spermatozoal MRNA Repertoires. Proc Royal Soc Biol B. (2012) Refereed Articles.
  • Konikoff, C. E., Karr, T. L., McCutchan, M., Newfeld, S. J. & Kumar, S.. Comparison of embryonic expression within multigene families using the FlyExpress discovery platform reveals more spatial than temporal divergence. Developmental Dynamics (2012) Refereed Articles.
  • Konikoff, C. E., Karr, T. L., McCutchan, M., Newfeld, S. J., and Kumar, S.. Comparison of embryonic expression within multigene families using the flyexpress discovery platform reveals more spatial than temporal divergence.. Dev Dyn (2012) Refereed Articles.
  • Vibranovski, M. D., Zhang, Y. E., Kemkemer, C., Lopes H. F., Betr?n, E., Karr, T. L., Long, M.. Re-analysis of the larval testis data on meiotic sex chromosome inactivation revealed evidence for tissue-specific gene expression related to the drosophila X chromosome. BMC Genomics (2012) Refereed Articles.
  • Vibranovski, M. D., Zhang, Y. E., Kemkemer, C., Lopes, H. F., Karr, T. L., and Long, M.. Re-analysis of the larval testis data on meiotic sex chromosome inactivation revealed evidence for tissuespecific gene expression related to the drosophila X chromosome.. BMC Biol (2012) Refereed Articles.
  • Vibranovski, M. D., Zhang, Y. E., Kemkemer, C., Vankuren, N. W., Lopes, H. F., Karr, T. L., and Long, M.. Segmental dataset and whole body expression data do not support the hypothesis that non-random movement is an intrinsic property of Drosophila retrogenes.. BMC Evol Biol (2012) Refereed Articles.

2011

  • Dorus, S., Wilkin, E. C. and Karr, T. L.. Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm. BMC Genomics (2011) Refereed Articles.
  • Dorus, S., Wilkin, E. C. and Karr, T. L.. Expansion and functional diversification of a leucyl aminopeptidase family that encodes the major protein constituents of Drosophila sperm.. BMC Genomics (2011) Refereed Articles.
  • Kumar, S., Konikoff, C., Van Emden, B., Busick, C., et al.. FlyExpress: visual mining of spatiotemporal patterns for genes and publications in Drosophila embryogenesis. Bioinformatics (2011) Refereed Articles.
  • Singh, R., Xu, J., and Kulathinal, R. J., Karr, T. L. and Dorus, S.. Proteomics and Reproduction. Evolutionary genomics of the sperm proteome (2011) Book Chapters.

2010

  • Dorus, S., Wasbrough, E. R., Busby, J., Wilkins, E. C. & Karr, T. L.. Sperm Proteomics Reveals Intensified Selection on Mouse Sperm Membrane and Acrosome Genes.. Mol Biol Evol (2010) Refereed Articles.
  • Elizabeth R. Wasbrough, Steve Dorus, Svenja Hester, Julie Howard-Murkin, Kathryn Lilley, Elaine Wilkin, Ashoka Polpitiya, Konstantinos Petritis, Timothy L. Karr. The Drosophila melanogaster sperm proteome-II (DmSP-II).. Journal of Proteomics (2010) Refereed Articles.
  • Vibranovski, M. D., Chalopin, D. S., Lopes, H. F., Long, M. & Karr, T. L.. Direct evidence for postmeiotic transcription during Drosophila melanogaster spermatogenesis.. Genetics (2010) Refereed Articles.

2009

  • Dorus, S., Parker, R., Busby, J., Busby, S., and Karr, T. L.. Comparative sperm proteomics of model vertebrate organisms: New players for and old idea.. Molecular Biology and Evolution (2009) Refereed Articles.
  • Gerike, U., Steeds, K. and Karr, T. L.. A 2D gel and mass spectrometric analysis of the Drosophila melanogaster sperm proteome. Proteomics (2009) Refereed Articles.
  • Heath, B. and Karr, T. L.. A new viral life cycle associated with diploid sex.. Science (2009) Refereed Articles.
  • Vibranovski, M. D. Lopes, H. F. , Karr, T. L., Long, M.. Meiotic X inactivation and its consequences to Drosophila melanogaster genes.. PLoS Genet (2009) Refereed Articles.
  • Vibranovski, M., Dorus, S., Long, M. and Karr, T. L.. The footprint of the Drosophila sperm proteome on the transcriptional landscape of spermatogenesis. PLoS Biology (2009) Refereed Articles.

2008

  • Dorus, S., Freeman, Z.N., Parker, E.R., Heath, B.D., and Karr, T.L.. Recent origins of sperm genes in Drosophila.. Molecular Biology and Evolution (2008) Refereed Articles.
  • Karr, T. L.. Application of proteomics to ecology and population biology.. Heredity (2008) Refereed Articles.
  • Karr, T. L. and Dorus, S.. Evolution of sperm proteomes. In Sperm Biology: an Evolutionary Approach (T.R. Birkhead, D.J. Hosken and S. Pitnick, eds.) pp 305-365.. (2008) Authored Books.
  • T.R. Birkhead, D.J. Hosken and S. Pitnick, Karr, T. L. and Dorus, S.. Sperm Biology: an Evolutionary Approach. Evolution of sperm proteomes (2008) Book Chapters.
  • T.R. Birkhead, D.J. Hosken and S. Pitnick, Karr, T. L., Snook, R.R. and Swanson, W.. Sperm Biology: an Evolutionary Approach. The evolutionary significance of variation in sperm-egg interactions. (2008) Book Chapters.