Energydisease

More about the science

Biological chemistry and drug design

An important new research initiative involves elucidating the chemical mechanism of mitochondrial energy production and an analysis of the effects of specific mitochondrial defects.  At present, we are focused on mitochondrial complexes I and II, and the way in which electrons are transported through these complexes, and then to complex III.  The strategy involves the use of substrate analogues and inhibitors, in conjunction with biochemical and cellular assays, to dissect function at the molecular level.

Biochemical drug classes include:


Inhibitors
Substrates
Uncouplers
Modulators